Exploring Molecular Contacts of MUC1 at CIN85 Binding Interface to Address Future Drug Design Efforts

The modulation of protein-protein interactions (PPIs) by small molecules represents a valuable strategy for pharmacological intervention in several human diseases. In this context, computer-aided drug discovery techniques offer useful resources to predict the network of interactions governing the recognition process between protein partners, thus furnishing relevant information for the design of novel PPI modulators. In this work, we focused our attention on the MUC1-CIN85 complex as a crucial PPI controlling cancer progression and metastasis. MUC1 is a transmembrane glycoprotein whose extracellular domain contains a variable number of tandem repeats (VNTRs) regions that are highly glycosylated in normal cells and under-glycosylated in cancer. The hypo-glycosylation fosters the exposure of the backbone to new interactions with other proteins, such as CIN85, that alter the intracellular signalling in tumour cells. Herein, different computational approaches were combined to investigate the molecular recognition pattern of MUC1-CIN85 PPI thus unveiling new structural information useful for the design of MUC1-CIN85 PPI inhibitors as potential anti-metastatic agents.     

Domain reversal and current transport property in BiFeO3 films

The electrical properties and domain reversal in BiFeO₃ ferroelectric films were studied using sandwiched heterostructures and piezoresponse force microscopy. A robust polarization state was observed, combined with a switchable domain pattern and a remanent polarization of approximately 100 μC cm^?2. In addition, domain reversal was explored using scanning probe microscopy. The results show that dipoles could be reversed along the direction of the electric field under a negative tip bias, leading to carrier gathering near the domain walls. The enhanced conductivity near the domain walls was owing to the discontinuous polarization boundary conditions. In addition, typical diode-like current transport properties are sensitive to various temperature conditions, which is attributed to the Schottky barriers at the contact interface. These findings extend the current understanding of domain texture reversal in ferroelectric films and shed light on their potential applications for future ferroelectric random-access memory operations over a wide temperature range.     

Room-temperature multiferroic characteristics and unique vortex domain structures of h-Yb1−xInxFeO3 solid solutions

Hexagonal rare-earth ferrites (h-RFeO₃) have attracted much scientific attention due to their room-temperature multiferroicity. However, it is still a hard job to obtain h-RFeO₃ bulk materials because of the meta-stability of such hexagonal phase, and the evaluation of room-temperature ferroelectric and magnetoelectric characteristics in such materials is also a challengeable issue. In the present work, Yb_1−xIn_xFeO₃ ceramics with the stable hexagonal structure were obtained by introducing chemical pressure, where the unique ferroelectric domain structures of sixfold vortex combined with tenfold vortex with a typical size of ~400 nm were determined. Symmetry of the present system evolved from centrosymmetric orthorhombic Pbnm (x = 0–0.4) to non-centrosymmetric hexagonal P6₃cm (x = 0.5 and 0.6) with a ferroelectric polarization up to 3.2 μC/cm², and finally to centrosymmetric hexagonal P6₃/mmc (x = 0.7 and 0.8). The Curie point decreased monotonically from 723 K to a temperature below room temperature with increasing x, and the antiferromagnetic phase transition above room temperature was determined for all compositions. Meanwhile, a large linear magnetoelectric coefficient (α_ME) up to 0.96 mV/cm Oe was obtained at room temperature, and this indicated the great application potential for magnetoelectric devices.     

When is it reasonable to implement the discontinuous sliding‐mode controllers instead of the continuous ones? Frequency domain criteria

Professor Utkin proposed an example showing that the amplitude of chattering caused by the presence of parasitic dynamics (stable actuators) in some systems governed by the First‐Order Sliding‐Mode Controller is lower than that produced by the Super‐Twisting Algorithm. This example served to motivate this paper reconsidering the problem of comparison of chattering in systems with stable actuators, and driven by Discontinuous Sliding‐Mode Controllers (DSMCs) and Continuous Sliding‐Mode Controllers (CSMCs). Comparison of chattering produced by DSMC and CSMC taking into account their amplitudes, frequencies, and average power (AP) needed to maintain the system into real‐sliding modes, allowing to conclude the following: (i) for systems with slow actuators, the amplitude of oscillations and AP produced by DSMC be smaller than those caused by CSMC; (ii) for bounded disturbances with fixed Lipschitz constant, there exist sufficiently fast actuators for which the amplitude of oscillations and AP produced by CSMC be smaller than those caused by DSMC.     

Human–Cyber–Physical Systems (HCPSs) in the Context of New-Generation Intelligent Manufacturing

An intelligent manufacturing system is a composite intelligent system comprising humans, cyber systems, and physical systems with the aim of achieving specific manufacturing goals at an optimized level. This kind of intelligent system is called a human–cyber–physical system (HCPS). In terms of technology, HCPSs can both reveal technological principles and form the technological architecture for intelligent manufacturing. It can be concluded that the essence of intelligent manufacturing is to design, construct, and apply HCPSs in various cases and at different levels. With advances in information technology, intelligent manufacturing has passed through the stages of digital manufacturing and digital-networked manufacturing, and is evolving toward new-generation intelligent manufacturing (NGIM). NGIM is characterized by the in-depth integration of new-generation artificial intelligence (AI) technology (i.e., enabling technology) with advanced manufacturing technology (i.e., root technology); it is the core driving force of the new industrial revolution. In this study, the evolutionary footprint of intelligent manufacturing is reviewed from the perspective of HCPSs, and the implications, characteristics, technical frame, and key technologies of HCPSs for NGIM are then discussed in depth. Finally, an outlook of the major challenges of HCPSs for NGIM is proposed.     

智能网联汽车变车距队列控制与仿真

智能网联汽车的发展是将来智能交通系统中的一个重要方向,受基础设施条件以及试验成本的限制,目前的测试验证仍以计算机仿真为主。针对现有仿真软件难以满足智能网联汽车测试需求的问题,以开源软件PLEXE为基础,通过对其道路交通模拟器中的车辆动力学模型、通信拓扑结构以及车辆队列控制器等关键模块进行二次开发,设计了面向智能网联汽车队列控制研究的可视化仿真平台,对变车距队列控制算法进行仿真验证。仿真结果表明:上述平台可完成队列控制的可视化仿真,相比其它软件更加直观形象。     

内阻尼对柔性连接转子系统稳定性的影响

工作在高速柔轴下的柔性连接转子容易发生转子动力学失稳，柔性连接处内阻尼是引起失稳的主要因素。采用Kelvin-Voigt黏弹性理论建立转子柔性连接的复刚度内阻尼模型，通过Kelvin-Voigt黏弹性理论损耗因子与转子模态测试得到复刚度模型中代表内阻尼的虚部系数，应用拉格朗日方法建立柔性连接转子系统的动力学方程。结合试验结果验证了模型的合理性，研究了连接处内阻尼和减振器动力学参数对转子系统稳定性的影响。结果表明，增大柔性连接处内阻尼会极大降低转子系统的稳定性，增大减振器中的刚度系数和减小折合质量可有效提高稳定性，系统的稳定性需从连接处和减振器两方面协调设计。     

域名管理体系与注册保护初探

域名具有重要的品牌价值,研究域名管理体系有利于开展域名注册与保护。现行域名注册规则容易导致域名与字号、商标、姓名等传统权利的冲突。互联网域种类繁多、层级结构复杂,企业应当建立域名注册评估机制、抢注侵权监测机制,加强域名注册与维权保护。     

跨领域文本情感分类研究进展

作为社会媒体文本情感分析的重要研究课题之一，跨领域文本情感分类旨在利用源领域资源或模型迁移地服务于目标领域的文本情感分类任务，其可以有效缓解目标领域中带标签数据不足问题.本文从三个角度对跨领域文本情感分类方法行了归纳总结：（1）按照目标领域中是否有带标签数据，可分为直推式和归纳式情感迁移方法；（2）按照不同情感适应性策略，可分为实例迁移方法、特征迁移方法、模型迁移方法、基于词典的方法、联合情感主题方法以及图模型方法等；（3）按照可用源领域个数，可分为单源和多源跨领域文本情感分类方法.此外，论文还介绍了深度迁移学习方法及其在跨领域文本情感分类的最新应用成果.最后，论文围绕跨领域文本情感分类面临的关键技术问题，对可能的突破方向进行了展望.     

基于词法特征的恶意域名快速检测算法

针对互联网中恶意域名攻击事件频发，现有域名检测方法实时性不强的问题，提出一种基于词法特征的恶意域名快速检测算法。该算法根据恶意域名的特点，首先将所有待测域名按照长度进行正则化处理后赋予权值；然后利用聚类算法将待测域名划分成多个小组，并利用改进的堆排序算法按照组内权值总和计算各域名小组优先级，根据优先级降序依次计算各域名小组中每一域名与黑名单上域名之间的编辑距离；最后依据编辑距离值快速判定恶意域名。算法运行结果表明，基于词法特征的恶意域名快速检测算法与单一使用域名语义和单一使用域名词法的恶意域名检测算法相比，准确率分别提高1.7%与2.5%，检测速率分别提高13.9%与6.8%，具有更高的准确率和实时性。